ACHIEVEMENT


*: Corresponding Author


Peer-Reviewed Original Papers


  1. Satoru Okuda*, Koichi Fuijimoto, "Mechanical instability leading to epithelial cell delamination," (under review) arXiv:1810.01984

  2. Satoru Okuda*, Erina Kuranaga, Katsuhiko Sato*, "Apical junctional fluctuations lead to cell flow while maintaining epithelial integrity," Biophysical Journal 116 (6): 1159-1170 (2019)

  3. Satoru Okuda*, Nozomu Takata, Yuiko Hasegawa, Masako Kawada, Yasuhiro Inoue, Taiji Adachi, Yoshiki Sasai, Mototsugu Eiraku* "Strain-triggered mechanical feedback in self-organizing optic cup morphogenesis," Science Advances 4(11): eaau1354 (2018)

  4. Satoru Okuda*, Katsuyuki Unoki, Mototsugu Eiraku, Ken-ichi Tsubota*, "Three-dimensional deformation mode of multicellular epithelial tube under tension and compression tests," Journal of Biomechanical Science and Engineering 13(4): 17-00507 (2018)

  5. Satoru Okuda*, Takashi Miura, Yasuhiro Inoue, Taiji, Adachi, Mototsugu Eiraku, "Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching," Scientific Reports 8: 2386 (2018)

  6. Atsushi Hashimoto, Atsuki Nagao, Satoru Okuda*, "Topological graph description of multicellular dynamics based on vertex model," Journal of Theoretical Biology 437: 187-201 (2018)

  7. Shoko Ito, Satoru Okuda, Masako Abe, Mari Fujimoto, Tetsuo Onuki, Tamako Nishimura, Masatoshi Takeichi*, "Induced cortical tension restores functional cell junctions to adhesion-defective carcinoma cells," Nature Communications 8(1):1834 (2017)

  8. Satoru Okuda*, Katsuyuki Unoki, Mototsugu Eiraku, Ken-ichi Tsubota*, "Contractile actin belt and mesh structures provide the opposite dependence of epithelial stiffness on the spontaneous curvature of constituent cells," Development, Growth & Differentiation 59(5): 455-464 (2017)

  9. Yasuhiro Inoue*, Tadashi Watanabe, Satoru Okuda, Taiji Adachi, "Mechanical role of the spatial patterns of contractile cells in invagination of growing epithelial tissue," Development, Growth & Differentiation 59(5): 444-454 (2017)

  10. Satoru Okuda*, Mototsugu Eiraku, "Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane," Biomechanics and Modeling in Mechanobiology 16(5): 1805-1818 (2017)

  11. Yuiko Hasegawa, Nozomu Takata, Satoru Okuda, Masako Kawada, Mototsugu Eiraku*, Yoshiki Sasai, "Emergence of dorsal-ventral polarity in ES cell-derived retinal tissue," Development 143 (21): 3895-3906 (2016) DOI: 10.1242/dev.134601

  12. Satoru Okuda*, Yasuhiro Inoue, Mototsugu Eiraku, Taiji Adachi, Yoshiki Sasai, "Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework," Biomechanics and Modeling in Mechanobiology 15(4): 805-816 (2016)

  13. Satoru Okuda*, Yasuhiro Inoue*, Tadashi Watanabe, Taiji Adachi, "Coupling intercellular molecular signaling with multicellular deformation for simulating 3D tissue morphogenesis," Royal Society Interface Focus 5: 20140095 (2015)

  14. Satoru Okuda*, Yasuhiro Inoue, Mototsugu Eiraku, Taiji Adachi, Yoshiki Sasai, "Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis," Biomechanics and Modeling in Mechanobiology 14(2), 413-425 (2015)

  15. Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi*, "Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-diinner-induced mechanical disturbance," Journal of Biomechanics 46(10): 1705-1713 (2013)

  16. Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi*, "Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework," Biomechanics and Modeling in Mechanobiology 12(5): 987-996 (2013)

  17. Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi*, "Reversible network reconnection model for simulating large deformation during dynamic tissue morphogenesis," Biomechanics and Modeling in Mechanobiology 12(4): 627-644 (2013)

  18. Satoru Okuda*, Takashi Uneyama, Yasuhiro Inoue, Yuichi Masubuchi, Masaki Hojo, "Soft-core interaction between entanglement segments for primitive chain network simulations," Journal of the Society of Rheology, Japan 40: 21-30 (2012)

  19. Mototsugu Eiraku, Nozomu Takata, Hiroki Ishibashi, Masako Kawada, Eriko Sakakura, Satoru Okuda, Kiyotoshi Sekiguchi, Taiji Adachi, Yoshiki Sasai*, "Self-organizing optic-cup morphogenesis in three-dimensional culture," Nature 472: 51-56 (2011)

  20. Satoru Okuda, Yasuhiro Inoue*, Yuichi Masubuchi, Takashi Uneyama, Masaki Hojo, "Wall boundary model for primitive chain network simulations," Journal of Chemical Physics 130: 214907-214913 (2009)



Review Articles


  1. Satoru Okuda*, Yasuhiro Inoue, Taiji Adachi, "Three-dimensional vertex model for simulating multicellular morphogenesis," Biophysics and Physicobiology 12: 13-20 (2015)

  2. Satoru Okuda*, Yasuhiro Inoue, Taiji Adachi, "Mechanics-based simulations for understanding multicellular tissue morphogenesis," Seibutsu Butsuri 54(1): 31-34 (2014)



Patents


  1. Satoru Okuda, Mototsugu Eiraku, Kuwahara Atsushi, "Region detecting method and region detecting device related to cell aggregate," Appeal/Trial number: WO 2017/09074 A1,25 Nov. 2016

    奥田覚,永樂元次,桑原篤, "細胞塊に関する領域検出方法及び領域検出装置," 出願番号:特願2015-229706,25 Nov. 2015 (in Japan)



Book Chapters


  1. 奥田覚 (2019). "1細胞統合モデルによる多細胞組織の形態予測," 生体の科学 70(4), 医学書院

  2. 奥田覚 (2019). "組織・器官の形成過程における細胞変形の原理とモデル化," Ed. 上野博夫,榎本篤,清川悦子, 病理と臨床 37(7), 文光堂

  3. 奥田覚, 永楽元次 (2019). "IV-7 三次元バーテックスモデルによる物理シミュレーションとオルガノイドへの応用," Ed. 佐藤俊朗,武部貴則,永樂元次, 実験医学 別冊 決定版 オルガノイド実験スタンダード, 羊土社

  4. 奥田覚, 永楽元次 (2017). "眼杯オルガノイド×Computational Biologyーin vitroとin silicoの相補的アプローチ," 実験医学 35(16): 2683-2688, 羊土社

  5. 奥田覚, 永楽元次 (2015). "器官をつくる―in vitro眼杯形成モデルと力学シミュレーションによる変形メカニズムの検証," 実験医学 33(3): 405-410, 羊土社

  6. 奥田覚, 井上康博, 安達泰治 (2014). "第4章4項2節 多細胞のダイナミクスに基づいた3次元組織形成シミュレーション," Ed. 田畑泰彦, MOOK 別冊 細胞の3次元組織化に不可欠な最先端材料技術, メディカルドゥ



Misc




Academic Presentation


2019


2018


2017


2016


2015


2014


2013


2012


2011


2010


2009


2008


Public Presentation


Award


Grant