We are developing new methods of mechanics-based simulations to analyze 3D multi-cellular dynamics such as embryogenesis and carcinogenesis. By combining this technology with biological experiments, we aim to reveal new aspects of the shaping of living organisms.
In the cultur, we let cells to create 3D tissues in a self-organizing manner and observe multi-cellular interactions during morphogenesis. We aim to understand and manipulate the multi-cellular dynamics by combining perturbation experiments and mechanics-based simulations.
Based on the quantitative data and understandings obtained from experiments and simulations, we extract and formulate various elementary processes of multi-cellular dynamics. We aim to discover the principles common to a wide range of physiology and pathophysiology.
under construction→3D VERTEX